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Consequently, an exhaustive examination of mitochondrial function and energy regulation mechanisms will establish the theoretical foundation for targeting mitochondria in cancer treatment

Int J Biochem Cell Biol 41(10):20512061 Mats JM, Segura JA, Martn-Rufin M, Campos-Sandoval JA, Alonso FJ, Mrquez J (2013) Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer

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On the other hand, the more tolerant of tobacco plants to pepper mild mottle virus (PMMoV-I) infection characterized decreased activity GR whereas OTC treated tolerant pea characterized GR upregulation ( Figure 2 3 Role of glutathione cycle in regulation of susceptible host-plant virus interaction In contrast to resistance, in susceptible plants, the generation of ROS is not well or properly controlled due to changes induced by plant virus infection in the host cell, particularly in the modulation of glutathione