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Phase 3 confirms benefits and compares the new drug with existing treatments in a larger population

10.1038/ncomms11624 78 Koch-HenriksenN.SorensenP

MED minimal erythema dose

SURPASS program: Tirzepatide in diabetes

Recent structures of transhydrogenase holoenzymes suggest new mechanistic details, how the long-distance coupling between hydride transfer in the peripheral nucleotide binding sites and the membrane-localized proton transfer occurs that now must be tested experimentally