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Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling

This enzyme is present in all living organisms and is a large homo-oligomeric complex composed of eight, ten, or twelve subunits assembled into two face-to-face rings 9

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This failure leads to neuronal swelling, disruption of dendritic architecture, and excessive neurotransmitter release, culminating in neurotransmitter-induced excitotoxicity (10, 29)