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The excess iron is transported to the extracellular space through the iron transporter protein, or stored in ferritin and reacted with intracellular H 2 O 2 to generate highly active hydroxyl radicals (OH) under slightly acidic conditions, which is known as the Fenton reaction (Fe 2+ + H 2 O 2 Fe 3+ + OH +OH)

Silica nanoparticles have a human track record in selected imaging applications, and phenolic nanomedicines have early clinical exposure in selected formulations, but the integrated MSN-phenolic redox oncology concept remains preclinical