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Tempisque is a village of 151 people and Jcara Arriba of 101

A two-arm pragmatic RCT with 233 IBS patients who were an average duration of 13 years found that compared with usual care, acupuncture treatment significantly reduced the IBS Symptom Severity Score (IBS-SSS) at 3 months [124]

220,258,259 While the efficacy of statins in alleviating DPN symptoms remains unclear, 260,261 emerging lipid-lowering therapies showed potential in improving nerve function in DPN models