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Today there are thousands of publications reporting on the functional and therapeutic benefits of curcumin mediated through its pleiotropic mechanisms of action in the context of many chronic diseases

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(4) mitochondrial metabolic output and cofactor availability as modulators of nuclear DNA modification

Instead, the authors suggest that an anti-inflammatory treatment targeting the inflammation itself may work better: The persistence of immunogenic PGBb material in inflamed joints provides a stronger rationale for targeting innate immune responses with medications, such as TNF or NF-B inhibitors, for the treatment of such patients