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Beyond the direct encoding of pain, anticipatory mechanisms have also been identified, with ipsilateral posterior cerebellar activation preceding noxious heat stimulation, suggesting a role in sensory prediction and pre-attentive processing (45)

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The product is designed for the particular purpose indicated on the label

While small-scale studies are ongoing, the transition to adequately powered trials with comparison groups remains a research priority for advancing regulatory policy and understanding

(59) Peak plasma concentrations occur at up to 9 hours post-ingestion (59)