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ABC multidrug transporters: structure, function and role in chemoresistance

Recent studies show GCN5L plays a key role in maintaining mitochondrial structure and function by regulating the acetylation modification network

Furthermore, artemisinin has been shown impair lysosomal function in lung cancer (A549/TAX) and breast cancer (MCF-7/ADR) cells, while subsequently improves the sensitivity of cancer cells to paclitaxel [119]

Nonetheless, the proteasome is involved in APP and APP-COOH-terminal fragment (CTF) metabolism and affects APP amyloidogenic and nonamyloidogenic processing

H 2 O 2 also mediates redox signaling through Nrf2, AMPK/PGC-1, and MAPK/ERK pathways, modulating antioxidant defense, metabolism, and cell survival ( To neutralize ROS, mitochondria use enzymatic systems including glutathione peroxidases (GPX1/4), which reduce H 2 O 2 and lipid peroxides using glutathione (GSH)