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Metabolic perturbations impair IR signaling cascades through JNK and IB kinase- (IKK) activation, leading to serine phosphorylation of IRS-1

They demonstrated that abemaciclib treatment resulted in significant apoptotic cell death in MCF-7, MDAMB231, and MDAMB468 cells via G0/G1 arrest and phosphorylation of RB1, chromatin condensation, upregulation of caspase3 and Bax levels, and downregulation of Bcl2 (Anwer et al

Similarly, Dings research team engineered a system linking two shRNA transcription plasmids targeting MDR-related genes (P-glycoprotein and survivin) to doxorubicin (DOX)-loaded DNA origami via disulfide bonds [57]

This is supported by Liu et al.s work demonstrating that PA could protect the rat liver against lead-induced injury by reducing ROS production, renewing the activities of antioxidant enzymes and decreasing DNA oxidative damage (Liu et al., 2012)

10.1016/S1474-4422(17)30161-8 133 MuangnoiC.JithavechP.Ratnatilaka Na BhuketP.SupasenaW.WichitnithadW.TowiwatP.et al (2018)