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Mitochondrial redox state, bioenergetics, and calcium transport in caloric restriction: a metabolic nexus

Inflammation haptocorrin levels can increase due to granulocyte activation or as an acute phase response Decreased clearance: Renal failure decreased clearance of transcobalaminB12 complexes Mechanism: Most elevated B12 is not free or biologically active , but rather bound to haptocorrin , which has a long half-life and is increased in certain diseases

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Zhou L, Ouyang R, Luo H et al (2018) Dysfunction of Nrf2-ARE signaling pathway: potential pathogenesis in the development of neurocognitive impairment in patients with moderate to severe obstructive sleep apnea-hypopnea syndrome