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Subsequently, Nuclear Factor Erythroid 2-related Factor 2 (NRF2) was identified as a transcription factor involved in regulating gene expression at these ARE sequences (Itoh et al., 1997

Ann Clin Transl Neurol 5:10891103

Rather than overriding pain signals, this model works to identify and address the root causes of chronic pain such as chronic inflammation, tissue injury, biomechanical imbalance, nutrient depletion, metabolic dysfunction, gut-immune disruption, or nervous system sensitization

81421005), Sanming Project of Medicine in Shenzhen (SZSM201801060), and the Natural Science Foundation of Hebei Province (Grant no

In the present article, the synthetic process of melanogenesis and associated core signaling pathways are summarized