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Among antiapoptotic changes, including decreasing p53, decreasing caspase 3 and increasing bcl-2/bcl-x or bax, most drugs induce more than one effect ( Figure 4 )

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Factors influencing VEGF expression include glucose deficiency and hypoxia (McConnell et al

The results obtained also show a further increase in glutathione peroxidase activity in the magnesium and insulin treated diabetic groups suggesting a potentiating effect of magnesium on the activity of this enzyme in these treatment groups (Table 2)

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