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It is not found in food, is not a naturally circulating hormone, and is not endogenously produced in measurable concentrations

"These additives are physically bound to plastics, which means they can leach into the water," Abraham says, Some research suggests that these additives, such as BPA, can interfere with our hormone function, and may be linked to increased risk of heart disease, stroke, diabetes and other chronic diseases

Gut 57, 747754 (2008)

If the redness expands beyond the circle in subsequent hours, the reaction is progressing and may need medical evaluation