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Diseases associated with iron overload Iron overload may arise from genetic predispositions, such as hereditary hemochromatosis [25] or ferroportin disease [26], as well as from acquired factors, including repeated red blood cell (RBC) transfusions due to anemia, increased intestinal iron absorption and ineffective erythropoiesis [27]

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In this regard, topical triple combination therapy containing hydroquinone 4%, tretinoin 0.05%, and fluocinolone 0.01% have received the Food and Drug Administration (FDA) approval in melasma management