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Metformin, macrophage dysfunction and atherosclerosis

Our group is currently conducting a randomized pilot study called PEGASUS (NCT05132244) at the BC Cancer Agency in Vancouver, Canada, to investigate the interplay between diabetes and PDAC by closely monitoring glucose levels in PDAC patients and associating its effect on clinical outcome (118)

Data from scRNA-seq and Western blot analyses of kidney tissues from mice with oxalate-induced AKI, along with observations of primary PTECs treated with CaOX, either alone or co-incubated with ferroptosis-specific inhibitors, demonstrated the occurrence of ferroptosis in renal tubular cells within the oxalate-induced AKI model

The high astrocyte specificity of MAO-B around dense-core A plaques enables more precise interrogation of astrocyte-related pathophysiology in the living brain in the context of neurodegenerative disease (Jaisa-Aad et al., 2024)

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