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[PubMed: 10922368] 525

Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML, et al

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Therapeutics Clinical trials targeting VEGF were initiated in the late 1990s based on the critical role of VEGF in cancer progression, with the first success in 2005 in patients with front-line metastatic breast cancer