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Lactate produced by glycolysis increases the lactylation level of PKM2 protein, which inhibits its tetramer-to-dimer transition, reducing nuclear distribution and enhancing its pyruvate kinase activity in the cytoplasm (48)

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We showed previously that the extent of IgE-mediated degranulation in mast cells exhibits temporal variations with peaks in the resting phase, dependent upon circadian regulation of FcRI expression and signaling by mast cell clock activity 21,44

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Glutaredoxin may act as a catalyst for the dissolution of mixed disulfide complexes when exposed to oxidative stress (Fig