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Blocking NNMT causes major weight loss, less fat mass and smaller fat cells (adipocytes), plus lower cholesterol and glucose in the blood

[DOI] [PMC free article] [PubMed] [Google Scholar] Yang W., Chang Z., Que R., Weng G., Deng B., Wang T., Huang Z., Xie F., Wei X., Yang Q., Li M., Ma K., Zhou F., Tang B., Mok V.C.T., Zhu S., Wang Q

To validate the screen findings, we generated epithelioids expressing KRas G12D from floxed Kras +/ G12D mice and their uninduced counterparts, and tested their ability to compete with wild-type cells

[DOI] [PMC free article] [PubMed] [Google Scholar] Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, et al