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Methionine supplementation decreased DNA methylation level and promoted the up-regulation of PPAR target genes angiopoietin like 4 (ANGPTL4), fibroblast growth factor 21 (FGF21), and phosphoenolpyruvate carboxykinase 1 (PCK1) in the liver

Catching up on sleep, such as by sleeping late on weekends, appears to mitigate, though may not completely reverse, some of the negative health effects of sleep loss