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Picein prevents scopolamine (HY-N0296)-induced passive avoidance memory impairment in rats

Pearce RG, Setzer RW, Strope CL et al (2017) Httk: R package for high-throughput toxicokinetics

doi:10.1371/journal.pone.0000625

In addition to a kinetic response to changes in Cys concentration, the catalytic turnover of Cys by CDO leads to conversion of CDO to its mature (Cys-Tyr cofactor-containing) form that has a markedly increased catalytic efficiency (k cat /K m ) and longer catalytic half-life, as discussed earlier

This effect of cannabis does not appear to reflect a neuroprotective effect and might be due to increased striatal dopamine levels by cannabis