glutathione reductase activity assay protocol measurement of Rapid and effective protocol to measure glutathione peroxidase Glutathione Reductase Assay principle. Abbreviations: GSH, glutathione;

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The cytoprotective (reduced reactive oxygen species and reduced cell senescence) effects of ergothioneine on endothelial cells exposed to hyperglycaemic conditions have been shown to be dependent on sirtuin 1 and sirtuin 6 activities and their cellular targets (Reference DOnofrio, Servillo and Giovane89) , which notably include NF- B, the aforementioned transcriptional regulator of SLC22A4 (Reference Maeda, Hirayama and Kobayashi63)

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Moreover, another type of FIN can induce ferroptosis by blocking the enzymatic activity of GPX4, such as RSL3, ML162, and ML210, thus achieving the inhibition of cancer [137, 138]