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Molecular Biology of Glutathione Peroxidase 4: From Genomic Structure to Developmental Expression and Neural Function. Biological Chemistry 388: 10071017

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Conversely, the genes most essential in cells with high mitochondrial GSH but with low cytosolic GSH due to BSO treatment were largely related to oxidative phosphorylation, indicating that cells with high mitochondrial GSH are still sensitive to mitochondrial dysfunction (Fig

Energy and cellular resources are being spent to make something the cell doesnt need to make

The skilled artisan would acknowledge that other methods, or a combination of other methods, may be applicable or desirable