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The core regulatory axes of ferroptosis primarily involve redox balance, lipid metabolism, iron regulation, and mitochondrial function ( Accumulating evidence indicates that ferroptosis critically contributes to the progression of diabetes and its complications via mechanisms involving lipid peroxidation and inflammation-activated neovascularization ( 2 Molecular mechanisms of ferroptosis: core regulatory pathways 2.1 Regulatory association between iron metabolism imbalance and ferroptosis Iron, an essential element for living organisms, serves as a crucial trace element in numerous biochemical reactions and plays a central role in fundamental physiological processes such as DNA synthesis, oxygen transport, and cellular energy production

The symptoms include loss of consciousness, post-injury amnesia, headaches, migraine, dizziness, light and sound sensitivity, seizures, blurred vision, anxiety, alterations in aggression, memory lapses, lack of impulse control, impaired decision making, and post-traumatic stress, etc

This accumulation was accompanied by enhanced expression of Gpx4 and Gsr, thereby strengthening redox cycling efficiency and providing essential metabolic support for sustained ROS generation and NETs formation

, 2013, vol

7b, c and Supplementary Fig