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Recent work shows that activating the SIRT3-FOXO3A axis promotes mitochondrial biogenesis and antioxidant enzyme expression [73]

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Furthermore, folinic acid supplementation in ASD subjects with low 5-MTHF levels in CSF leads to the normalization of folate levels and alleviates some symptoms of ASD ( There are several examples of enzyme deficiencies in methionine cycle (CBS, SAHHD, MTHFR) with clinical presentation of ASD