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Genes in the blue module were enriched in various inflammatory response-related biological processes, such as response to lipopolysaccharide and cytokine activity ( Supplementary Figure 2A ), and KEGG analysis revealed significant enrichment in classical RA-related immune-inflammatory pathways such as IL-17 signaling pathway, TNF signaling pathway, and NF-kappaB signaling pathway ( Supplementary Figure 2B ), suggesting that this module may participate in the regulation of pro-inflammatory signaling in RA

Peng L, Bestard-Lorigados I, Song W

Science (2003) 300(5622):114851.10.1126/science.1081315 10 HemmiHTakeuchiOSatoSYamamotoMKaishoTSanjoHet alThe roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

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It binds with the cyanide molecules to convert it into cyanocobalamin which is then excreted via urination resulting in cyanide detoxification