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S-oxidation of thioureylenes catalyzed by a microsomal flavoprotein mixed-function oxidase

Nevertheless, under physiological conditions, in most tissues mitochondria are the major contributors to the cellular ROS production [28,29,30,31], mainly as a side effect of aerobic respiration via oxidative phosphorylation (OXPHOS) occurring on the inner membrane of the mitochondrion [32, 33], but also through other metabolic routes, such as pentose-phosphate pathway and glutathione (GSH) metabolism [34]

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Nucleotide depletion itself triggers p53 stabilization, and we confirmed that both MPA and Pyr caused this effect in HT-1080 Control cells (Fig 4A)

Peyronies disease is a condition in which plaque or scar tissue is formed within the tunica albuginea of the penis