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Due to its role in DNA synthesis and red blood cell formation, B12 deficiency may result in anaemia (with symptoms such as pallor, dizziness, palpitations and shortness of breath) and damaged mucous membranes

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The clinical relevance of this finding is unclear because additional studies have failed to demonstrate its significance, as explained later in this Chapter

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The signals triggered by the antibody in normal effectors, which are predominantly CD38 + and FcR + , are one of the most important findings obtained from in vivo MM therapy