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In high doses, opioids can depress the brain's drive to breath -- this respiratory depression is the main cause of fatal overdoses

Funding Statement This research received no external funding

The hypothesis that B12 could modulate CCL11 expression during persistent VCD via methyl-dependent epigenetic mechanisms was confirmed by the hypermethylation of DML a and c in leukocytes from cultures of impaired individuals incubated with the vitamin

At the same time, TT, in an HDM mouse model of asthma, decreased epithelial cell hypertrophy and mucus production [73]

and their case records would be updated accordingly to indicate this self-defined dietary restriction