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Considering the presence of B cells and Breg-like populations in BrM, EV-mediated phenotypes are relevant in metastasis to the CNS, where they may contribute to local immune suppression, TLS formation, and impact therapeutic potential in treating BrM

The narrow extracellular space does not widen at the fiber threefold axes (arrows), revealing a narrow and tortuous route for diffusion of molecules through extracellular spaces