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In preparing this review, we selected the most robust and relevant preclinical data to illustrate the therapeutic promise of natural products

Key features Selected peptidic fraction from Saccharomyces cerevisiae Clinically proven benefits on a total of 135 subjects Reduction of caloric intake significant after the first weeks (down to -600kcal/day after 8 weeks) Significant weight loss after the first month Weight loss is from fat mass reduction Abdominal fat and waist circumference significantly decrease Water-soluble and heat-resistant

This might be responsible for the low IGF-I levels seen in association with states of insulin resistance, as the metabolic syndrome[301]

MN was initially conceptualized in the 1970 s by Martin S