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Description

This warrants further investigation in future studies

FASEB journal: official publication of the Federation of American Societies for Experimental Biology

This 83-amino-acid polypeptide features a key structural modification: a substitution of arginine for glutamic acid at position 3, along with a 13-amino-acid N-terminal extension

doi: 10.1186/1758-5996-6-80

Consequently, A2AR blockade enhances T cell effector function while inducing ferroptosis due to increased lipid peroxidation, which provides a mechanistic explanation for the recent observations of decreased survival of tumor-infiltrating A2AR-deficient T cells (46) or activated CD73-deficient CD8 + T cells under antigenic stimulation (47)