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In contrast to the secretion and mRNA expression of t-PA, the secretion and gene expression of type 1 plasminogen activation inhibitor in human endothelial and smooth muscle cells is enhanced by homocysteine (Midorikawa et al, 2000)

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For example, after coated with a silica layer, the zinc dioxide (ZnO) NPs exhibited less cytotoxicity in human dermal fibroblast cells with less enzyme leakage, ROS production, and oxidative stress than their bare NPs, as a result of the surface modification restricting formation of free radicals and the release rate of zinc ions, as well as reducing the surface interactions of ZnO NPs with cells (Ramasamy et al., 2014)

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BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality