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FIGURE 3 3.1 Inducing Factors of Ferroptosis 3.1.1 Iron (Fe 2+ ) Metabolism As an indispensable cofactor in many enzyme metabolism processes and a catalyst of redox-cycling reaction (Stoyanovsky et al., 2019), iron is involved in a variety of important physiological and biochemical processes in vivo

CNS Drugs 2017;31:1057-82

Precise definition of safety windows represents a key challenge

Liver-related symptoms include vomiting, weakness, fluid build-up in the abdomen, swelling of the legs, yellowish skin, and itchiness

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