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Recent findings suggest that pathological tau can spread trans-synaptically, accelerating neurodegeneration in a prion-like fashion (Meng et al., 2023)

Yao, Tao Zhang, Xian-Tao Zeng, Ji-Hong Feng, Xue Xiao Journal: International immunopharmacology Journal ranking: Q1 Key takeaways: Synthetic thymic peptides, particularly thymosin 1, combined with chemotherapy significantly improve patient quality of life and survival rates in non-small cell lung cancer

[Abstract]2024 Jun 15:134:112159

thus, AChE may be the relevant target site of the two chemicals against mites 46

In experimental models of AF and in atrial appendage samples from patients with AF, cardiomyocyte autophagy was found to be activated by enhanced ER stress, which could be attenuated by treatment with the chemical chaperone 4-PBA 2+ levels increase, there is activation of calpain 1, a Ca 2+ -dependent neutral cysteine protease, in both paroxysmal and persistent AF, which, alongside autophagy, further enhances myolysis [177]