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The pathogenesis and the pathophysiology of sepsis is very complicated and multifaceted: numerous biological mechanisms, such as infection, inflammation, oxidative stress, immune system dysregulation, blood coagulation, endothelium dysfunction, tissue damage, elevated cellular death and/or apoptosis are involved during sepsis at tissue, cellular and molecular levels causing a damaging systemic reaction [379]

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In addition to ATF4, CHOP plays a critical role in regulating CHAC1 during UFR (Mungrue et al., 2009)

This association remained significant in regression models adjusted for age, sex, and initial clinical severity [adjusted-OR = 0.014 (95%CI = 0.0010.810), p = 0.039]

Venous blood sampling Venous blood samples were obtained from the antecubital vein into a 10 ml collection tubes using a standard vacutainer apparatus into one tube for serum separation and one for whole blood