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The modifiability and functional integration of customized nanomaterials present a promising opportunity to simultaneously block multiple metabolic pathways, and a variety of strategies have been developed to modulate tumor metabolism (glycolysis or fatty acid synthesis pathway) in combination with chemotherapy, radiotherapy, or immunotherapy to achieve multiple-punch to tumors 46,47

10.1016/j.phymed.2013.09.020 105 RauA

(162) showed upregulated expression of the integrin molecule CD103 on peripheral blood, BALF, and intrathoracic lymph node biopsy specimens in patients with sarcoidosis, indirectly confirming a theory of migration of such cells into inflammatory foci

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The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease