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Published 2021 Dec 20

AOD-9604 is not currently approved by the U.S

Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth

Here, stabilized HIF-1 upregulates glycolytic enzymes and pro-inflammatory cytokines, while ROS bursts promote NLRP3 inflammasome assembly, leading to GSDMD cleavage and the release of IL-1 and IL-18 (Xueqiang et al., 2025)

Results and discussion General results In the initial search, a total of 542 published works were identified, 25 in the LILACS database, 486 in PubMed and 31 records in SciElo