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IGF-1 peptides (LR3, Des) increase systemic or local IGF-1 levels potentially supporting musculoskeletal repair alongside muscle effects

Firstly, lactate represents a convenient metabolic substrate for energy-deprived neurons, since, as compared to glucose, its use reduces the strain on the depleted energy levels

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Drug Testing and Analysis (2020) 12

However, its lack of specificity remains a major limitation: NfL levels can rise following surgical procedures or systemic stress and thus cannot be used in isolation to infer neuroprotective efficacy