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These proteins are the major proteins observed across all mammalian species, which suggests important biological functions (97, 98, 107)

It reduces oxidative stress by inhibiting cytochrome C oxidase, the final enzyme in the electron transport chain connected to membrane potential of mitochondria

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Depletion of Wapl prevents cohesin release from mitotic chromosomes, leading to defective sister-chromatid resolution, impaired chromosome condensation, and segregation errors 48,50