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A number of approaches targeting deficient GCase activity in GBA-PD have reached the stage of clinical phase 2/3 trials including orally active GCase chaperones to enhance enzymatic activity, substrate reduction therapies modelling current treatment of Gauchers disease and GBA gene therapy (Table 5)

Pyroptosis Pyroptosis is a distinct form of RCD characterized by the activation of inflammasomes and inflammation-associated caspases [136]

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For example, a SAML assertion can be encrypted using XML-Encryption, while an OpenID Connect ID Token can be encrypted using JSON Web Encryption (JWE)