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injection Digoxin elimination follows first-order kinetics Following intravenous administration to healthy volunteers, 50% to 70% of a digoxin dose is excreted unchanged in the urine Renal excretion of digoxin is proportional to glomerular filtration rate and is largely independent of urine flow In healthy volunteers with normal renal function, digoxin has a half-life of 1.5 to 2.0 days Side Effects: Note: Digoxin's TI is relatively low (~2) Adverse effects are dose-dependent and typically occur at doses higher than those needed to achieve a therapeutic effect

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The ability of GH to advance the pubertal maturation in GH-deficient children [20, 21, 22, 23] and in GH-replete normal male rats [24] further illustrates the importance of GH in pubertal development

On that basis, tesamorelin has the higher-tier and more recent human data multiple randomized, placebo-controlled Phase 3 trials while sermorelins human record is older and narrower

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