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CLA (Conjugated Linoleic Acid) is a natural fatty acid that helps reduce body fat by increasing fat oxidation and reducing fat storage

For example, raloxifene, a selective estrogen receptor modulator used in therapy of osteoporosis, naturally has a low bioavailability and has also been shown to be extensively metabolised by UGT1A8 and UGT1A10 (Kemp et al., 2002)