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DM is a heterogeneous group of diseases classified into different clinical categories with distinct etiologies that can involve a complex interplay of genetic, autoimmune, and environmental factors, leading to widespread metabolic dysfunction and pathological alterations in various tissues and organs, including bone tissue (Skyler 2004

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In the context of CIRS, where low VEGF is often paralleled by fatigue and cognitive dulling, Rhodiolas dual impact on perfusion and mitochondrial function may offer a multipronged benefit

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