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A Phase II trial in patients with non-small-cell lung cancer reported improved survival in patients treated with ARQ197 and erlotinib when compared to erlotinibmonotherapy(Mayor, 2011)

While challenges in translating findings from animal models to human patients due to differences in important factors such as IVD size, cell turnover, and biomechanical load need to be acknowledged and carefully considered, the usefulness of these experimental models cannot be ignored