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An emerging alternative hypothesis is that partial agonism of MOR can lead to reduced side effects while preserving therapeutic effects (signaling efficacy hypothesis) 78,91

synbiotics and psychobiotics seek to enhance effect sizes by pairing strains with substrate specificity and targeting mood/cognition-relevant circuits [242,243,244,245]

Science 276 , 20422045 (1997)

Alexandria, VA: U.S

Horowitz, MD, is the founder of the Pain Management Department of the prestigious Brooklyn Premier Orthopedics and Center for Musculoskeletal Disorders