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The results revealed that the IGHV mutational status was a key determinant of sensitivity, with mutated CLL cells being significantly more responsive to ferroptosis induction than unmutated cells (Fig

Ka, Kb, Kp and Kq are the Km values for the corresponding substrates and products, and Keq is the equilibrium constant of the reaction ( Supplementary Table S1 )

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For the experiments on hypoglycemic effect and inhibition of hepatic glucose production, one-way ANOVA followed by Tukey post hoc tests were performed for intergroup analysis, while repeated measures ANOVA followed by Dunnett post hoc tests were applied for intragroup analysis