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Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

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Polymorphisms in genes like CYP26B1 and RAR are associated with HTs severity and Th17 polarization, indicating a potential role for vitamin A in modulating immune responses in this condition [129]

Assessment and improvement of statistical tools for comparative proteomics analysis of sparse data sets with few experimental replicates