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Astrocyte cultures from DJ-1 KO mice treated with lipopolysaccharide have increased NO production and an up-regulation of different pro-inflammatory mediators like COX-2 and IL-6 (Waak et al., 2009)

Tardito S, Oudin A, Ahmed SU, Fack F, Keunen O, Zheng L, Miletic H, Sakariassen P, Weinstock A, Wagner A, Lindsay SL, Hock AK, Barnett SC, Ruppin E, Mrkve SH, Lund-Johansen M, Chalmers AJ, Bjerkvig R, Niclou SP, Gottlieb E

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Alexa 647 and Alexa 488 were used as dyes

This view aligns with mathematical predictions of the total oxidative stress burden that circulating (or stored) RBCs may face, which is a function of hemoglobin autoxidation and directly proportional to the variance in the total number of hemoglobin molecules per cell