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Global metabolomics analysis Global metabolomic profiling of primary tumours and PDX samples was performed using the analytical DiscoveryHD4 platform by Metabolon 59

Vitamin B12 is essential for neurologic function, red blood cell creation, and DNA synthesis and is a coenzyme for three primary biochemical conversions: homocysteine to methionine, 5-methyltetrahydrofolate to tetrahydrofolate, and methylmalonic acid to succinyl coenzyme A [1, 2]

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Keating MJ, OBrien S, Lerner S, Giles F, Andreeff M , Cortes J, Albitar M, Kantarjian H