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LoBuglioAFWheelerRHTrangJHaynesARogersKHarveyEBet alMouse/human chimeric monoclonal antibody in man: kinetics and immune response

The use of partial agonists is a common strategy in drug development (212)

This metabolic reprogramming increases Gln utilization in CRPC [121,141,187]

In this regard, it is interesting that IgG antibodies that show similar FcRn binding properties can have variable plasma half-lives due to differences in biophysical properties, such as pI and net charge, which affect cellular handling 83,84,85,86,87